The Sirius Phenotypic
Resilience Framework
A peer-review grade systems-biology specification standardizing multi-year electronic health records into the OHDSI OMOP Common Data Model (CDM v5.4) to quantify Primary Aging, Secondary Degradation, and Dynamic Functional Reserve.
Disentangling Primary Aging from Secondary Degradation
Conventional medicine frequently conflates immutable thermodynamic entropy with reversible allostatic wear. In the SiriusHealth architecture, biological decay is modeled as a compounding non-linear differential equation:
The basal thermodynamic decay that occurs even in an idealized environment: telomere shortening, basal mitochondrial ROS leakage, and epigenetic noise.
Modulation: NAD+ pool restoration, autophagy induction, and Sirtuin activation.Accelerated damage from exogenous stressors: advanced glycation end-products (AGEs), vascular homocysteine shearing, sleep apnea, and sedentary micro-hypoxia.
Characteristic: Highly variable, non-linear, and 100% preventable/reversible.The 2D Resilience-Frailty Matrix
Decoupling static resting biomarker damage from dynamic physiological muscle buffer:
The Compounding Master
Pristine resting blood lab panels combined with robust musculoskeletal power (high grip strength, low sitting hours). Demonstrates maximum kinetic reserve against sudden clinical events.
The Athletic Ageless
High cardiorespiratory and muscle power, but internal allostatic stress (elevated homocysteine, high stress, or subclinical inflammation) is actively wearing vascular endothelium.
The Sedentary Compensated
Resting lab panels appear normal on routine checkups, but prolonged daily sitting (>9 hrs) and low skeletal muscle mass create zero physical reserve. High vulnerability upon physical challenge.
The Frail Decompensated
Accelerated multi-organ biomarker decay coupled with sarcopenia and physical frailty. High risk of multi-organ cascade failure upon acute infection or hospitalization.
The 4 Organ Subsystems Measured
Our algorithms decompose biological age into four discrete, standardized organ decay vectors:
1. Metabolic Resilience
LOINC: 1558-6 (Glucose), 14927-8 (Triglycerides), 2085-9 (HDL), 4548-4 (HbA1c)
Measures subclinical insulin resistance and lipotoxicity years before diabetes or metabolic fatty liver triggers formal clinical diagnostic codes.
2. Inflammatory & Vascular Tone
LOINC: 30522-7 (hs-CRP), 13965-9 (Homocysteine), 788-0 (RDW), 1751-7 (Albumin)
Quantifies chronic low-grade vascular endothelial irritation and immunosenescence—the primary upstream catalyst for cardiovascular plaque rupture and arterial stiffening.
3. Renal & Microvascular
LOINC: 2160-0 (Creatinine), 3094-0 (BUN), 8480-6 (Systolic BP)
Tracks microvascular glomerular filtration pressure, arterial pulse pressure elasticity, and protein wasting.
4. Hepatic & Cellular Turnover
LOINC: 1742-6 (ALT), 1920-8 (AST), 6768-6 (ALP), 1975-2 (Bilirubin)
Detects early enzymatic congestion, bile acid regulation, and metabolic liver lipid accumulation.
The 5 Structured Human Optimization Protocols
Translating upstream phenotypic geroscience into practical, daily life systems:
1. Sleep & Glymphatic Protocol
The brain only clears metabolic waste and amyloid-beta during slow-wave deep sleep. Racing thoughts are calmed by clearing elevated catecholamines.
- ✓ 65°–68°F cold, 100% blackout bedroom
- ✓ 30-sec contrast cold shower shock before bed
- ✓ 300mg Magnesium L-Threonate & 4-7-8 breathwork
2. Lifestyle & Nutrition Protocol
Eliminating synthetic additives and supporting the cellular methylation cycle to protect vascular endothelium.
- ✓ Zero synthetic folic acid / enriched flours
- ✓ L-Methylfolate + TMG + Pastured choline
- ✓ Stable glycemic profile (HbA1c ≤ 5.2%)
3. Work & Movement Protocol
Longevity scales with daily slope and continuous physical mobility, preventing sarcopenia and insulin insensitivity.
- ✓ 3-min movement snack every 45 min of sitting
- ✓ Progressive incline slope walking 3x / week
- ✓ Heavy carries & dead hangs for grip reserve
4. Mental & Neuro-Autonomic
Counteracting social isolation and chronic sympathetic overdrive through oxytocin stimulation and COMT enzymatic regulation.
- ✓ Oxytocin stimulation (hugs > 6s, pets, community)
- ✓ Intergenerational purpose & de-isolation
- ✓ SAMe & B-complex for COMT stress clearance
5. The SiriusHealth Clinical Protocol
Transforming routine hospital EHRs and lab draws into automated, continuous trajectory surveillance and proactive deprescribing.
Request the Full Technical White Paper (PDF)
Subscribe to receive the complete 28-page scientific specification featuring exact Gompertz hazard modeling equations, full LOINC/SNOMED data dictionaries, and tri-model AI ingestion blueprints.
Test the Dual-Axis Phenotypic Engine
Experience our computable geroscience algorithms firsthand through the 3-step triage simulator or connect your care center via our REST API.